LMPD Database

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LMP001103

UniProt Annotations

Entry Information
Gene Namezinc finger, DHHC domain containing 3
Protein EntryZDHC3_MOUSE
UniProt IDQ8R173
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityPalmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
DomainThe DHHC domain is required for palmitoyltransferase activity.
FunctionPalmitoyltransferase with broad specificity. Palmitoylates GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3), which regulates synaptic clustering and/or cell surface stability. Palmitoylates glutamate receptors GRIA1 and GRIA2, which leads to their retention in Golgi. {ECO:0000269|PubMed:15229235, ECO:0000269|PubMed:15603741, ECO:0000269|PubMed:16129400}.
PtmAutopalmitoylated.
SimilarityBelongs to the DHHC palmitoyltransferase family. {ECO:0000305}.
SimilarityContains 1 DHHC-type zinc finger. {ECO:0000255|PROSITE-ProRule:PRU00067}.
Subcellular LocationGolgi apparatus membrane {ECO:0000269|PubMed:12163046, ECO:0000269|PubMed:15229235, ECO:0000269|PubMed:16129400}; Multi-pass membrane protein {ECO:0000269|PubMed:12163046, ECO:0000269|PubMed:15229235, ECO:0000269|PubMed:16129400}.
Tissue SpecificityWidely expressed, with highest levels in brain. In the brain, expressed only in neurons (at protein level). {ECO:0000269|PubMed:12163046, ECO:0000269|PubMed:15229235, ECO:0000269|PubMed:15603741}.