LMPD Database

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LMP001097

UniProt Annotations

Entry Information
Gene Namephospholipase C, beta 2
Protein EntryQ9BVT6_HUMAN
UniProt IDQ9BVT6
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q00722-1; Sequence=Displayed; Name=2; IsoId=Q00722-2; Sequence=VSP_035770; Name=3; IsoId=Q00722-3; Sequence=VSP_054490; Note=No experimental confirmation available.;
Catalytic Activity1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
CofactorName=Ca(2+); Xref=ChEBI
FunctionThe production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
MiscellaneousThe receptor-mediated activation of PLC-beta-2 is most effectively mediated by one G-protein alpha subunit, alpha- 16.
SimilarityContains 1 C2 domain. {ECO
SimilarityContains 1 PI-PLC X-box domain. {ECO
SimilarityContains 1 PI-PLC Y-box domain. {ECO
SubunitInteracts with RAC1.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/PLCB2ID41743ch15q15.html";