LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP001082

UniProt Annotations

Entry Information
Gene Namephospholipase A2, group IVA (cytosolic, calcium-dependent)
Protein EntryPA24A_MOUSE
UniProt IDP47713
SpeciesMouse
Comments
Comment typeDescription
Catalytic Activity2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate.
Catalytic ActivityPhosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate.
DomainThe N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+) (By similarity). {ECO:0000250}.
Enzyme RegulationStimulated by agonists such as ATP, EGF, thrombin and bradykinin as well as by cytosolic Ca(2+).
FunctionSelectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.
PtmActivated by phosphorylation at both Ser-505 and Ser-726. {ECO:0000269|PubMed:10978317, ECO:0000269|PubMed:19144319}.
SimilarityContains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
SimilarityContains 1 PLA2c domain. {ECO:0000255|PROSITE- ProRule:PRU00555}.
Subcellular LocationCytoplasm. Cytoplasmic vesicle. Note=Translocates to membrane vesicles in a calcium-dependent fashion.