LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP001079

UniProt Annotations

Entry Information
Gene Namemitochondrial trans-2-enoyl-CoA reductase
Protein EntryMECR_HUMAN
UniProt IDQ9BV79
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BV79-1; Sequence=Displayed; Name=2; IsoId=Q9BV79-2; Sequence=VSP_041131; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=37 uM for trans-2-hexenoyl-CoA {ECO
Catalytic ActivityAcyl-CoA + NADP(+) = trans-2,3-dehydroacyl-CoA + NADPH. {ECO
FunctionOxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2- decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis.
Sequence CautionSequence=AAD34058.1; Type=Frameshift; Positions=14, 19; Evidence= ;
SimilarityBelongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
Subcellular LocationMitochondrion .
SubunitHomodimer. {ECO
Tissue SpecificityHighly expressed in skeletal and heart muscle. Expressed at lower level in placenta, liver, kidney and pancreas. Weakly or not expressed in lung.