LMPD Database

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LMP001064

UniProt Annotations

Entry Information
Gene Namephosphatidylserine synthase 2
Protein EntryPTSS2_MOUSE
UniProt IDQ9Z1X2
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Z1X2-1; Sequence=Displayed; Name=2; IsoId=Q9Z1X2-2; Sequence=VSP_010637, VSP_010638;
Catalytic ActivityL-1-phosphatidylethanolamine + L-serine = L-1- phosphatidylserine + ethanolamine.
Disruption PhenotypeNull mice exhibit a reduction of more than 95% in serine exchange in testis and approximately 90% reduction in brain and liver. Testis weight is reduced and some animals are infertile. Elimination of either Pss1 or Pss2, but not both, is compatible with mouse viability. Mice can tolerate as little as 10% serine-exchange activity and are viable with small amounts of phosphatidylserine and phosphatidylethanolamine content. {ECO:0000269|PubMed:12361952, ECO:0000269|PubMed:18343815}.
Enzyme RegulationAlmost complete inhibition by ethanolamine in both the mitochondria-associated membrane (MAM) and endoplasmic reticulum (ER) per se. {ECO:0000269|PubMed:10938271}.
FunctionCatalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. PTDSS2 is specific for phosphatatidylethanolamine and does not act on phosphatidylcholine. {ECO:0000269|PubMed:10432300}.
PathwayPhospholipid metabolism; phosphatidylserine biosynthesis.
SimilarityBelongs to the phosphatidyl serine synthase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:10938271}; Multi-pass membrane protein {ECO:0000269|PubMed:10938271}. Note=Highly enriched in the mitochondria-associated membrane (MAM).
Tissue SpecificityHighly expressed in testis. Detected at lower levels in kidney and heart. {ECO:0000269|PubMed:10432300, ECO:0000269|PubMed:12361952}.