LMPD Database

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LMP001040

UniProt Annotations

Entry Information
Gene Nameenoyl-CoA delta isomerase 2
Protein EntryECI2_HUMAN
UniProt IDO75521
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O75521-1; Sequence=Displayed; Name=2; IsoId=O75521-2; Sequence=VSP_037854;
Catalytic Activity(3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl- CoA.
CautionIt is uncertain whether Met-1 or Met-3 is the initiator.
FunctionAble to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates (By similarity).
Sequence CautionSequence=AAC19317.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ; Sequence=AAD34173.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=AAF66247.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=AAH02668.3; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=AAH16781.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ; Sequence=AAH17474.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ; Sequence=AAH33841.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ; Sequence=AAH34702.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ; Sequence=BAG52068.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ;
SimilarityContains 1 ACB (acyl-CoA-binding) domain.
SimilarityIn the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
Subcellular LocationIsoform 1: Mitochondrion .
Subcellular LocationIsoform 2: Peroxisome matrix.
Tissue SpecificityAbundant in heart, skeletal muscle and liver. Expressed in CD34(+) T-cells and CD34(+) bone marrow cells.