LMPD Database

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LMP001003

UniProt Annotations

Entry Information
Gene Namefatty acyl CoA reductase 2
Protein EntryFACR2_MOUSE
UniProt IDQ7TNT2
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TNT2-1; Sequence=Displayed; Name=2; IsoId=Q7TNT2-2; Sequence=VSP_021682; Note=No experimental confirmation available.;
Catalytic ActivityHexadecanal + CoA + NADP(+) = hexadecanoyl-CoA + NADPH.
FunctionCatalyzes the reduction of fatty acyl-CoA to fatty alcohols. The preferred substrates are C16, C18, C18:1 and C18:2 but low activity can be observed with C10-C14 substrates. {ECO:0000269|PubMed:15220348}.
SimilarityBelongs to the fatty acyl-CoA reductase family. {ECO:0000305}.
Subcellular LocationPeroxisome membrane {ECO:0000305}; Multi- pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Peroxisome in cells expressing low levels of the protein. Peroxisome and endoplasmic reticulum in cells expressing high levels of the protein (Potential). {ECO:0000305}.
Tissue SpecificityHighly expressed in the meibomian glands of the eyelid and the sebaceous glands of the skin. Expressed in the brain where large quantities of ether lipids are synthesized. {ECO:0000269|PubMed:15220348}.