LMPD Database

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LMP000944

Record overview

LMPD IDLMP000944
Gene ID5571
SpeciesHomo sapiens (Human)
Gene Nameprotein kinase, AMP-activated, gamma 1 non-catalytic subunit
Gene SymbolPRKAG1
SynonymsAMPKG
Alternate names5'-AMP-activated protein kinase subunit gamma-1;,AMPK gamma1; AMPK gamma-1 chain', "5'-AMP-activated protein kinase, gamma-1 subunit
Chromosome12
Map Location12q12-q14
SummaryThe protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for PRKAG1

Proteins

5'-AMP-activated protein kinase subunit gamma-1 isoform 1
Refseq ID:NP_002724
Protein GI:4506061
UniProt ID:P54619
mRNA ID:NM_002733
Length:331
RefSeq Status:REVIEWED
METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYK
SALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGT
YANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRL
VVVDENDVVKGIVSLSDILQALVLTGGEKKP
 
5'-AMP-activated protein kinase subunit gamma-1 isoform 3
Refseq ID:NP_001193638
Protein GI:332000015
UniProt ID:P54619
mRNA ID:NM_001206709
Length:340
RefSeq Status:REVIEWED
METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVVLRALSCPLGMLTITDF
INILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSK
SLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINR
LVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP
 
5'-AMP-activated protein kinase subunit gamma-1 isoform 4
Refseq ID:NP_001193639
Protein GI:332000017
UniProt ID:P54619
mRNA ID:NM_001206710
Length:299
RefSeq Status:REVIEWED
MKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCI
SPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVD
EKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP