LMPD Database

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LMP000938

UniProt Annotations

Entry Information
Gene Namenuclear receptor subfamily 1, group H, member 2
Protein EntryNR1H2_MOUSE
UniProt IDQ60644
SpeciesMouse
Comments
Comment typeDescription
FunctionNuclear receptor. Binds preferentially to double- stranded oligonucleotide direct repeats having the consensus half- site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism. {ECO:0000269|PubMed:18055760, ECO:0000269|PubMed:19520913, ECO:0000269|PubMed:20427281}.
InteractionQ96EB6:SIRT1 (xeno); NbExp=2; IntAct=EBI-5276809, EBI-1802965;
SimilarityBelongs to the nuclear hormone receptor family. NR1 subfamily. {ECO:0000305}.
SimilarityContains 1 nuclear receptor DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00407}.
Subcellular LocationNucleus {ECO:0000255|PROSITE- ProRule:PRU00407}.
SubunitForms a heterodimer with RXR.
Tissue SpecificityUbiquitous.