LMPD Database

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LMP000929

UniProt Annotations

Entry Information
Gene Namephospholipase A2, group XIIA
Protein EntryPG12A_MOUSE
UniProt IDQ9EPR2
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9EPR2-1; Sequence=Displayed; Name=2; IsoId=Q9EPR2-2; Sequence=VSP_004509;
Catalytic ActivityPhosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate. {ECO:0000255|PROSITE- ProRule:PRU10035}.
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000250};
FunctionPA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl- phosphatidylcholine or -phosphatidylethanolamine (By similarity). {ECO:0000250}.
SimilarityBelongs to the phospholipase A2 family. {ECO:0000305}.
Subcellular LocationSecreted. Cytoplasm {ECO:0000250}.