LMPD Database

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LMP000923

UniProt Annotations

Entry Information
Gene Namediacylglycerol kinase, theta 110kDa
Protein EntryDGKQ_HUMAN
UniProt IDP52824
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityATP + 1,2-diacyl-sn-glycerol = ADP + 1,2- diacyl-sn-glycerol 3-phosphate.
DomainThe L-X-X-L-L repeats are implicated in binding to the nuclear receptor NR5A1.
Enzyme RegulationInactivated by binding to RHOA. Not inhibited by phosphatidylserine.
FunctionPhosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of protein kinase C by controlling the balance between these two signaling lipids. Activated in the nucleus in response to alpha-thrombin and nerve growth factor (By similarity). May be involved in cAMP- induced activation of NR5A1 and subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically with NR5A1 on CYP17 transcriptional activity.
PtmPhosphorylated by PRKCE and PRKCH in vitro.
SimilarityBelongs to the eukaryotic diacylglycerol kinase family.
SimilarityContains 1 DAGKc domain. {ECO
SimilarityContains 1 Ras-associating domain.
SimilarityContains 3 phorbol-ester/DAG-type zinc fingers.
Subcellular LocationCytoplasm. Cell membrane. Cytoplasm, cytoskeleton. Nucleus. Nucleus speckle. Note=Translocates to the nucleus in response to thrombin stimulation (By similarity). Translocates to the plasma membrane in response to steroid hormone receptor stimulation. Translocation to the plasma membrane is dependent on G-protein coupled receptor stimulation and subsequent activation of PRKCE and probably PRKCH.
SubunitInteracts with RHOA (constitutively activated, GTP- bound); the interaction inhibits DGKQ. Interacts with PRKCE. Interacts with PRKCH. Interacts with PLCB1. Interacts with NR5A1; the interaction requires the LXXLL motif 1 and LXXLL motif 2 in DGKQ. {ECO