LMPD Database

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LMP000901

UniProt Annotations

Entry Information
Gene Namelysophospholipase 1
Protein EntryLYPA1_MOUSE
UniProt IDP97823
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P97823-1; Sequence=Displayed; Name=2; IsoId=P97823-2; Sequence=VSP_009197; Note=May be due to an intron retention. No experimental confirmation available.;
Catalytic ActivityPalmitoyl-protein + H(2)O = palmitate + protein.
FunctionHydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity (By similarity). {ECO:0000250}.
Sequence CautionSequence=BAC34318.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the AB hydrolase superfamily. AB hydrolase 2 family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000250}.
SubunitHomodimer. {ECO:0000250}.