LMPD Database

LMP000894

Gene Information

Entrez Gene ID	5740
Gene Name	prostaglandin I2 (prostacyclin) synthase
Gene Symbol	PTGIS
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005901	IDA:UniProtKB	C	caveola
GO:0005783	IDA:UniProtKB	C	endoplasmic reticulum
GO:0005789	TAS:Reactome	C	endoplasmic reticulum membrane
GO:0005615	ISS:UniProtKB	C	extracellular space
GO:0016021	IEA:UniProtKB-KW	C	integral component of membrane
GO:0005634	IDA:UniProtKB	C	nucleus
GO:0020037	IDA:UniProtKB	F	heme binding
GO:0005506	IEA:InterPro	F	iron ion binding
GO:0004497	IEA:InterPro	F	monooxygenase activity
GO:0016705	IEA:InterPro	F	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0008116	IDA:UniProtKB	F	prostaglandin-I synthase activity
GO:0097190	IDA:UniProtKB	P	apoptotic signaling pathway
GO:0019369	TAS:Reactome	P	arachidonic acid metabolic process
GO:0071456	IDA:UniProtKB	P	cellular response to hypoxia
GO:0071347	IEP:UniProtKB	P	cellular response to interleukin-1
GO:0071354	IEP:UniProtKB	P	cellular response to interleukin-6
GO:0019371	TAS:Reactome	P	cyclooxygenase pathway
GO:0006690	TAS:Reactome	P	icosanoid metabolic process
GO:0050728	IDA:UniProtKB	P	negative regulation of inflammatory response
GO:0032088	IDA:UniProtKB	P	negative regulation of NF-kappaB transcription factor activity
GO:0045019	IDA:UniProtKB	P	negative regulation of nitric oxide biosynthetic process
GO:0045766	IMP:UniProtKB	P	positive regulation of angiogenesis
GO:1900119	IDA:UniProtKB	P	positive regulation of execution phase of apoptosis
GO:0035360	IDA:UniProtKB	P	positive regulation of peroxisome proliferator activated receptor signaling pathway
GO:0001516	IDA:UniProtKB	P	prostaglandin biosynthetic process
GO:0044281	TAS:Reactome	P	small molecule metabolic process
GO:0006805	TAS:Reactome	P	xenobiotic metabolic process

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_150149	Synthesis of Prostaglandins (PG) and Thromboxanes (TX)