LMPD Database

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LMP000879

UniProt Annotations

Entry Information
Gene Namesteroid 5 alpha-reductase 2
Protein EntryS5A2_MOUSE
UniProt IDQ99N99
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityA 3-oxo-5-alpha-steroid + NADP(+) = a 3-oxo- Delta(4)-steroid + NADPH.
FunctionConverts testosterone (T) into 5-alpha- dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology (By similarity). {ECO:0000250}.
SimilarityBelongs to the steroid 5-alpha reductase family. {ECO:0000305}.
Subcellular LocationMicrosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.