LMPD Database

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LMP000878

UniProt Annotations

Entry Information
Gene Namesedoheptulokinase
Protein EntrySHPK_MOUSE
UniProt IDQ9D5J6
SpeciesMouse
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=0.19 mM for sedoheptulose {ECO:0000269|PubMed:18775706}; Vmax=0.128 nmol/min/mg enzyme (at 30 degrees Celsius) {ECO:0000269|PubMed:18775706};
Catalytic ActivityATP + sedoheptulose = ADP + sedoheptulose 7- phosphate. {ECO:0000269|PubMed:22682222}.
FunctionActs as a modulator of macrophage activation through control of glucose metabolism. {ECO:0000269|PubMed:18775706, ECO:0000269|PubMed:22682222}.
InductionUp-regulated by IL-4 and IL-13. Down-regulated by LPS. {ECO:0000269|PubMed:22682222}.
SimilarityBelongs to the FGGY kinase family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:22682222}.