LMPD Database

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LMP000877

UniProt Annotations

Entry Information
Gene Namephospholipase A2, group VI
Protein EntryPLPL9_MOUSE
UniProt IDP97819
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=Long; Synonyms=iPLA2-L; IsoId=P97819-1; Sequence=Displayed; Name=Short; Synonyms=iPLA2-S; IsoId=P97819-2; Sequence=VSP_044364;
Catalytic ActivityPhosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate.
Enzyme RegulationInhibited by calcium-activated calmodulin. {ECO:0000250}.
FunctionCatalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F- actin polymerization at the pseudopods (By similarity). {ECO:0000250}.
SimilarityContains 1 patatin domain. {ECO:0000305}.
SimilarityContains 7 ANK repeats. {ECO:0000255|PROSITE- ProRule:PRU00023}.
Subcellular LocationIsoform Long: Membrane; Peripheral membrane protein. Note=Recruited to the membrane-enriched pseudopod upon MCP1/CCL2 stimulation in monocytes. {ECO:0000250}.
Subcellular LocationIsoform Short: Cytoplasm.