LMPD Database

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LMP000876

UniProt Annotations

Entry Information
Gene Nameacyl-CoA synthetase medium-chain family member 1
Protein EntryACSM1_MOUSE
UniProt IDQ91VA0
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91VA0-1; Sequence=Displayed; Name=2; IsoId=Q91VA0-2; Sequence=VSP_028392; Note=No experimental confirmation available.;
Catalytic ActivityATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA.
Catalytic ActivityGTP + lipoate = diphosphate + lipoyl-GMP.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
FunctionFunctions as GTP-dependent lipoate-activating enzyme that generates the substrate for lipoyltransferase (By similarity). Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro). {ECO:0000250, ECO:0000269|PubMed:11470804}.
SimilarityBelongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}.
Subcellular LocationMitochondrion matrix {ECO:0000269|PubMed:11470804}.
SubunitMonomer. {ECO:0000250}.
Tissue SpecificityHighly expressed in liver and kidney. {ECO:0000269|PubMed:11470804}.