LMPD Database

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LMP000873

UniProt Annotations

Entry Information
Gene Nameperoxisomal trans-2-enoyl-CoA reductase
Protein EntryPECR_MOUSE
UniProt IDQ99MZ7
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityAcyl-CoA + NADP(+) = trans-2,3-dehydroacyl-CoA + NADPH.
FunctionParticipates in chain elongation of fatty acids. Has no 2,4-dienoyl-CoA reductase activity (By similarity). {ECO:0000250}.
PathwayLipid metabolism; fatty acid biosynthesis.
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular LocationPeroxisome {ECO:0000250}.
SubunitInteracts with PEX5, probably required to target it into peroxisomes. {ECO:0000250}.
Tissue SpecificityHighly expressed in liver and kidney. Expressed at lowe level in heart and skeletal muscle. Expressed at weak level in other tissues. {ECO:0000269|PubMed:10811639}.