LMPD Database

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LMP000867

UniProt Annotations

Entry Information
Gene Nameperoxisome proliferator activator receptor delta
Protein EntryPPARD_MOUSE
UniProt IDP35396
SpeciesMouse
Comments
Comment typeDescription
FunctionLigand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand (By similarity). {ECO:0000250}.
Sequence CautionSequence=AAA03332.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the nuclear hormone receptor family. NR1 subfamily. {ECO:0000305}.
SimilarityContains 1 nuclear receptor DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00407}.
Subcellular LocationNucleus.
SubunitHeterodimer with the retinoid X receptor.
Tissue SpecificityHeart, adrenal and intestine.