LMPD Database

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LMP000856

UniProt Annotations

Entry Information
Gene Namephospholipase C, gamma 2
Protein EntryPLCG2_MOUSE
UniProt IDQ8CIH5
SpeciesMouse
Comments
Comment typeDescription
Catalytic Activity1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250};
FunctionThe production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling (By similarity). {ECO:0000250}.
InteractionP14753:Epor; NbExp=2; IntAct=EBI-617954, EBI-617901; O70433:Fhl2; NbExp=3; IntAct=EBI-617954, EBI-299379; Q8BTM8:Flna; NbExp=3; IntAct=EBI-617954, EBI-641991; P11276:Fn1; NbExp=6; IntAct=EBI-617954, EBI-641955; Q9ES52:Inpp5d; NbExp=3; IntAct=EBI-617954, EBI-300210; P25911:Lyn; NbExp=2; IntAct=EBI-617954, EBI-643537; Q9WU78:Pdcd6ip; NbExp=7; IntAct=EBI-617954, EBI-641897; Q62158:Trim27; NbExp=4; IntAct=EBI-617954, EBI-642025; Q64321:Zbtb7b; NbExp=3; IntAct=EBI-617954, EBI-642868;
PtmPhosphorylated on tyrosine residues by BTK and SYK; upon ligand-induced activation of a variety of growth factor receptors and immune system receptors. Phosphorylation leads to increased phospholipase activity (By similarity). Phosphorylated on tyrosine residues by CSF1R. {ECO:0000250, ECO:0000269|PubMed:17947660, ECO:0000269|PubMed:9312046}.
SimilarityContains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
SimilarityContains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
SimilarityContains 1 PI-PLC X-box domain. {ECO:0000255|PROSITE- ProRule:PRU00270}.
SimilarityContains 1 PI-PLC Y-box domain. {ECO:0000255|PROSITE- ProRule:PRU00271}.
SimilarityContains 1 SH3 domain. {ECO:0000255|PROSITE- ProRule:PRU00192}.
SimilarityContains 2 SH2 domains. {ECO:0000255|PROSITE- ProRule:PRU00191}.
SubunitInteracts (via SH2 domain) with CSF1R (tyrosine phosphorylated). {ECO:0000269|PubMed:9312046}.