LMPD Database

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LMP000825

UniProt Annotations

Entry Information
Gene Namelow density lipoprotein receptor-related protein associated protein 1
Protein EntryAMRP_MOUSE
UniProt IDP55302
SpeciesMouse
Comments
Comment typeDescription
FunctionInteracts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330.
SimilarityBelongs to the alpha-2-MRAP family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum {ECO:0000255|PROSITE- ProRule:PRU10138}. Cytoplasm {ECO:0000250}. Cell surface {ECO:0000250}. Note=Intracellular and associated with cell surface receptors. Found in the endoplasmic reticulum (By similarity). {ECO:0000250}.
SubunitPresent on cell surface forming a complex with the alpha- 2-macroglobulin receptor heavy and light chains. Binds LRP1B; binding is followed by internalization and degradation (By similarity). {ECO:0000250}.
Tissue SpecificityHighly expressed in PYS-2 parietal endoderm cells and in the kidney. The RNA level increased about 10-fold during differentiation of F9 embryonal carcinoma cells to parietal endoderm cells. {ECO:0000269|PubMed:2229028}.