LMPD Database

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LMP000822

UniProt Annotations

Entry Information
Gene Namechemokine (C-X-C motif) ligand 16
Protein EntryCXL16_MOUSE
UniProt IDQ8BSU2
SpeciesMouse
Comments
Comment typeDescription
FunctionInduces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. Also acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis. {ECO:0000269|PubMed:11060282}.
PtmGlycosylated. {ECO:0000250}.
SimilarityBelongs to the intercrine alpha (chemokine CxC) family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Tissue SpecificityWidely expressed. Not detected in purified B- and T-cells. {ECO:0000269|PubMed:11017100, ECO:0000269|PubMed:20675388}.