LMPD Database

LMP000810

Gene Information

Entrez Gene ID	5728
Gene Name	phosphatase and tensin homolog
Gene Symbol	PTEN
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005737	IDA:HPA	C	cytoplasm
GO:0043197	IEA:Ensembl	C	dendritic spine
GO:0005739	IEA:Ensembl	C	mitochondrion
GO:0035749	IEA:Ensembl	C	myelin sheath adaxonal region
GO:0005634	IDA:HPA	C	nucleus
GO:0045211	IEA:Ensembl	C	postsynaptic membrane
GO:0043220	IEA:Ensembl	C	Schmidt-Lanterman incisure
GO:0000287	IEA:InterPro	F	magnesium ion binding
GO:0016314	IEA:InterPro	F	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
GO:0051800	IEA:InterPro	F	phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
GO:0004725	IEA:InterPro	F	protein tyrosine phosphatase activity
GO:0008138	IEA:InterPro	F	protein tyrosine/serine/threonine phosphatase activity
GO:0007092	IEA:Ensembl	P	activation of mitotic anaphase-promoting complex activity
GO:0007568	IEA:Ensembl	P	aging
GO:0001525	IEA:Ensembl	P	angiogenesis
GO:0048738	IEA:Ensembl	P	cardiac muscle tissue development
GO:0032286	IEA:Ensembl	P	central nervous system myelin maintenance
GO:0021955	IEA:Ensembl	P	central nervous system neuron axonogenesis
GO:0060997	IEA:Ensembl	P	dendritic spine morphogenesis
GO:0021542	IEA:Ensembl	P	dentate gyrus development
GO:0043542	IEA:Ensembl	P	endothelial cell migration
GO:0048853	IEA:Ensembl	P	forebrain morphogenesis
GO:0046855	IEA:InterPro	P	inositol phosphate dephosphorylation
GO:0045475	IEA:Ensembl	P	locomotor rhythm
GO:0060292	IEA:Ensembl	P	long term synaptic depression
GO:0060291	IEA:Ensembl	P	long-term synaptic potentiation
GO:0060179	IEA:Ensembl	P	male mating behavior
GO:0042711	IEA:Ensembl	P	maternal behavior
GO:0007613	IEA:Ensembl	P	memory
GO:0033555	IEA:Ensembl	P	multicellular organismal response to stress
GO:0043066	IEA:Ensembl	P	negative regulation of apoptotic process
GO:0050771	IEA:Ensembl	P	negative regulation of axonogenesis
GO:0090344	IEA:Ensembl	P	negative regulation of cell aging
GO:0030336	IEA:InterPro	P	negative regulation of cell migration
GO:0045792	IEA:Ensembl	P	negative regulation of cell size
GO:0061002	IEA:Ensembl	P	negative regulation of dendritic spine morphogenesis
GO:0050680	IEA:Ensembl	P	negative regulation of epithelial cell proliferation
GO:0090394	IEA:Ensembl	P	negative regulation of excitatory postsynaptic membrane potential
GO:0051895	IEA:InterPro	P	negative regulation of focal adhesion assembly
GO:0031642	IEA:Ensembl	P	negative regulation of myelination
GO:0046621	IEA:Ensembl	P	negative regulation of organ growth
GO:0050765	IEA:Ensembl	P	negative regulation of phagocytosis
GO:0051898	IEA:Ensembl	P	negative regulation of protein kinase B signaling
GO:0090071	IEA:Ensembl	P	negative regulation of ribosome biogenesis
GO:2000808	IEA:Ensembl	P	negative regulation of synaptic vesicle clustering
GO:0007270	IEA:Ensembl	P	neuron-neuron synaptic transmission
GO:0046856	IEA:InterPro	P	phosphatidylinositol dephosphorylation
GO:0048008	IEA:Ensembl	P	platelet-derived growth factor receptor signaling pathway
GO:0043065	IEA:Ensembl	P	positive regulation of apoptotic process
GO:2001235	IEA:Ensembl	P	positive regulation of apoptotic signaling pathway
GO:0008284	IEA:Ensembl	P	positive regulation of cell proliferation
GO:2000463	IEA:Ensembl	P	positive regulation of excitatory postsynaptic membrane potential
GO:0097107	IEA:Ensembl	P	postsynaptic density assembly
GO:0060134	IEA:Ensembl	P	prepulse inhibition
GO:0097105	IEA:Ensembl	P	presynaptic membrane assembly
GO:0060736	IEA:Ensembl	P	prostate gland growth
GO:0043491	IEA:Ensembl	P	protein kinase B signaling
GO:0002902	IEA:Ensembl	P	regulation of B cell apoptotic process
GO:0033032	IEA:Ensembl	P	regulation of myeloid cell apoptotic process
GO:0031647	IEA:InterPro	P	regulation of protein stability
GO:0046685	IEA:Ensembl	P	response to arsenic-containing substance
GO:0033198	IEA:Ensembl	P	response to ATP
GO:0042493	IEA:Ensembl	P	response to drug
GO:0032355	IEA:Ensembl	P	response to estradiol
GO:0045471	IEA:Ensembl	P	response to ethanol
GO:0009749	IEA:Ensembl	P	response to glucose
GO:0007584	IEA:Ensembl	P	response to nutrient
GO:0010043	IEA:Ensembl	P	response to zinc ion
GO:0060024	IEA:Ensembl	P	rhythmic synaptic transmission
GO:0035176	IEA:Ensembl	P	social behavior
GO:0060074	IEA:Ensembl	P	synapse maturation

KEGG Pathway Links

KEGG Pathway ID	Description
hsa04068	FoxO signaling pathway
hsa05161	Hepatitis B
hsa05206	MicroRNAs in cancer
hsa04151	PI3K-Akt signaling pathway