LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP000801

UniProt Annotations

Entry Information
Gene NameELOVL fatty acid elongase 2
Protein EntryELOV2_HUMAN
UniProt IDQ9NXB9
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityA very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO(2).
DomainThe di-lysine motif may confer endoplasmic reticulum localization.
FunctionCondensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. {ECO
PathwayLipid metabolism; polyunsaturated fatty acid biosynthesis. {ECO
SimilarityBelongs to the ELO family.
Subcellular LocationEndoplasmic reticulum membrane ; Multi-pass membrane protein .
Tissue SpecificityLiver and testis.