LMPD Database

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LMP000793

UniProt Annotations

Entry Information
Gene Namephospholipase A2, group IIF
Protein EntryPA2GF_MOUSE
UniProt IDQ9QZT4
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9QZT4-1; Sequence=Displayed; Name=2; IsoId=Q9QZT4-2; Sequence=VSP_037525;
Biophysicochemical PropertiespH dependence: Optimum pH is 6.0-7.0. {ECO:0000269|PubMed:10531313};
Catalytic ActivityPhosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate. {ECO:0000255|PROSITE- ProRule:PRU10035}.
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per subunit.;
Developmental StageStrongly expressed during embryogenesis. {ECO:0000269|PubMed:10531313}.
FunctionPA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Hydrolyzes phosphatidylglycerol with a stronger preference as compared to phosphatidylcholine. {ECO:0000269|PubMed:10531313}.
SimilarityBelongs to the phospholipase A2 family. {ECO:0000305}.
Subcellular LocationSecreted.
Tissue SpecificityStrongly expressed in testis. {ECO:0000269|PubMed:10531313}.