LMPD Database

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LMP000727

UniProt Annotations

Entry Information
Gene Name3'(2'), 5'-bisphosphate nucleotidase 1
Protein EntryBPNT1_HUMAN
UniProt IDV9HWF9
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=O95861-1; Sequence=Displayed; Name=2; IsoId=O95861-2; Sequence=VSP_009937; Note=No experimental confirmation available.; Name=3; IsoId=O95861-3; Sequence=VSP_054807; Name=4; IsoId=O95861-4; Sequence=VSP_054808;
Catalytic ActivityAdenosine 3',5'-bisphosphate + H(2)O = adenosine 5'-phosphate + phosphate.
CofactorName=Mg(2+); Xref=ChEBI
Enzyme RegulationUncompetitive inhibition by micromolar concentrations of lithium. Competitive inhibition by inositol 1,4- bisphosphate.
FunctionConverts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4- trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6.
SimilarityBelongs to the inositol monophosphatase family.
Tissue SpecificityHighly expressed in kidney, liver, pancreas and heart. Detected at lower levels in brain, placenta, lung and skeletal muscle.