LMPD Database

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LMP000714

UniProt Annotations

Entry Information
Gene NameGPI anchor attachment protein 1
Protein EntryGPAA1_MOUSE
UniProt IDQ9WTK3
SpeciesMouse
Comments
Comment typeDescription
FunctionEssential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate. {ECO:0000269|PubMed:10793132, ECO:0000269|PubMed:10898732}.
PathwayGlycolipid biosynthesis; glycosylphosphatidylinositol- anchor biosynthesis.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
SubunitForms a complex with PIGK/GPI8, PIGT, PIGU and PIGS. {ECO:0000269|PubMed:10793132}.
Tissue SpecificityUbiquitously expressed in fetal and adult tissues. Expressed at higher levels in fetal tissues than adult tissues. In embryos abundant in the choroid plexus, skeletal muscle,. {ECO:0000269|PubMed:10898732}.