LMPD Database

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LMP000696

UniProt Annotations

Entry Information
Gene Namevery low density lipoprotein receptor
Protein EntryVLDLR_MOUSE
UniProt IDP98156
SpeciesMouse
Comments
Comment typeDescription
FunctionBinds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation.
MiscellaneousLRP8 and VLVLR together are required for correct embryonic development in the brain. Targeted disruption of both genes results in a phenotype virtually indistinguishable from that seen in "reeler" and "scrambler" mice. Subtle effects of VLDLR deletion are found mainly in the cerebellum, whereas lack of LRP8 predominantly affects the positioning of the neurons in the neocortex.
PtmUbiquitinated at Lys-839 by MYLIP leading to degradation. {ECO:0000250}.
SimilarityContains 3 EGF-like domains. {ECO:0000255|PROSITE- ProRule:PRU00076}.
SimilarityContains 6 LDL-receptor class B repeats. {ECO:0000255|PROSITE-ProRule:PRU00461}.
SimilarityContains 8 LDL-receptor class A domains. {ECO:0000255|PROSITE-ProRule:PRU00124}.
Subcellular LocationMembrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein.
SubunitBinds to the extracellular matrix protein Reelin. Interacts with DAB1. Interacts with VLDLR. Interacts with SNX17. Interacts with PCSK9 (By similarity). {ECO:0000250}.
Tissue SpecificityAbundant in heart and muscle; less in kidney, brain, ovary, testis, lung and adipose tissue.