LMPD Database

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LMP000695

UniProt Annotations

Entry Information
Gene Namevery low density lipoprotein receptor
Protein EntryVLDLR_HUMAN
UniProt IDP98155
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=Long; IsoId=P98155-1; Sequence=Displayed; Name=Short; IsoId=P98155-2; Sequence=VSP_004304;
DiseaseCerebellar ataxia, mental retardation, and dysequilibrium syndrome 1 (CAMRQ1) [MIM
FunctionBinds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity).
InteractionP30533:LRPAP1; NbExp=4; IntAct=EBI-9004309, EBI-715927; Q99068:Lrpap1 (xeno); NbExp=2; IntAct=EBI-9004309, EBI-919734; Q60841:Reln (xeno); NbExp=4; IntAct=EBI-9004309, EBI-9248666;
PtmUbiquitinated at Lys-839 by MYLIP leading to degradation.
SimilarityContains 3 EGF-like domains. {ECO
SimilarityContains 6 LDL-receptor class B repeats.
SimilarityContains 8 LDL-receptor class A domains.
Subcellular LocationMembrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein.
SubunitBinds to the extracellular matrix protein Reelin. Interacts with VLDLR. Interacts with SNX17 (By similarity). Interacts with DAB1. Receptor for the minor-group human rhinoviruses (HRVs); binds protein VP1 through the second and third LDL-receptor class A domains. Interacts with PCSK9. {ECO
Tissue SpecificityAbundant in heart and skeletal muscle; also ovary and kidney; not in liver.
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/vldlr/";