LMPD Database

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LMP000679

UniProt Annotations

Entry Information
Gene Nameceramide synthase 2
Protein EntryCERS2_MOUSE
UniProt IDQ924Z4
SpeciesMouse
Comments
Comment typeDescription
FunctionSuppresses the growth of cancer cells. May be involved in sphingolipid synthesis (By similarity). {ECO:0000250}.
SimilarityContains 1 homeobox DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00108}.
SimilarityContains 1 TLC (TRAM/LAG1/CLN8) domain. {ECO:0000255|PROSITE-ProRule:PRU00205}.
Subcellular LocationNucleus membrane {ECO:0000255|PROSITE- ProRule:PRU00108}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:15823095}; Multi-pass membrane protein {ECO:0000269|PubMed:15823095}.
SubunitInteracts with ATP6V0C, ASGR1, ASGR2 and SLC22A1/OCT1. {ECO:0000250}.
Tissue SpecificityBroadly expressed, with highest levels in liver and kidney. {ECO:0000269|PubMed:15823095}.