LMPD Database

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LMP000674

UniProt Annotations

Entry Information
Gene Namenuclear receptor subfamily 2, group F, member 2
Protein EntryCOT2_HUMAN
UniProt IDP24468
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=P24468-1; Sequence=Displayed; Name=2; IsoId=P24468-2; Sequence=VSP_042630; Name=3; IsoId=P24468-3; Sequence=VSP_043897;
DiseaseCongenital heart defects, multiple types, 4 (CHTD4) [MIM
FunctionLigand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A. {ECO
SimilarityBelongs to the nuclear hormone receptor family. NR2 subfamily.
SimilarityContains 1 nuclear receptor DNA-binding domain.
Subcellular LocationNucleus.
SubunitInteracts with SQSTM1 (By similarity). Binds DNA as a dimer; homodimer or heterodimer with NR2F6. Interacts with NCOA1, NCOA2, NCOA3 and PPARGC1A. Interacts with ZFPM2 (By similarity).
Tissue SpecificityUbiquitous.