LMPD Database

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LMP000672

UniProt Annotations

Entry Information
Gene Namemilk fat globule-EGF factor 8 protein
Protein EntryQ3TDU5_MOUSE
UniProt IDQ3TDU5
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Long; IsoId=P21956-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=P21956-2; Sequence=VSP_009880;
Developmental StageIsoform 1 and isoform 2 are detectable in mammary tissue from non-pregnant animals, with isoform 2 being predominant. Levels of isoform 1 increase during gestation and lactation while levels of isoform 2 decrease. {ECO:0000269|PubMed:2122462, ECO:0000269|PubMed:9920772}.
DomainThe F5/8 type C 2 domain mediates high-affinity binding to phosphatidylserine-containing membranes.
FunctionContributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha- v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction (By similarity). Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization. {ECO:0000250, ECO:0000269|PubMed:15834428, ECO:0000269|PubMed:18008006}.
InductionIsoform 1 is induced by insulin, prolactin and hydrocortisone in mammary epithelial cells. Expression of isoform 2 is repressed by the same treatment. {ECO:0000269|PubMed:9920772}.
PtmN-glycosylated. Isoform 1 also exists in both an O- glycosylated and a non-O-glycosylated form. {ECO:0000269|PubMed:9920772}.
SimilarityContains 2 EGF-like domains. {ECO:0000255|PROSITE- ProRule:PRU00076}.
SimilarityContains 2 F5/8 type C domains. {ECO:0000255|PROSITE- ProRule:PRU00081}.
Subcellular LocationMembrane {ECO:0000269|PubMed:2122462}; Peripheral membrane protein {ECO:0000269|PubMed:2122462}. Secreted {ECO:0000269|PubMed:2122462}.
Tissue SpecificityMammary epithelial cell surfaces and spermatozoan. Isoform 2 is present in brain, heart, kidney and spleen and at low levels in lung, liver, small intestine and testis. {ECO:0000269|PubMed:2122462, ECO:0000269|PubMed:9920772}.