LMPD Database

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LMP000671

UniProt Annotations

Entry Information
Gene Nameprostaglandin E synthase 3 (cytosolic)
Protein EntryTEBP_HUMAN
UniProt IDQ15185
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q15185-1; Sequence=Displayed; Name=2; IsoId=Q15185-2; Sequence=VSP_055363; Note=No experimental confirmation available.; Name=3; IsoId=Q15185-3; Sequence=VSP_055364; Note=No experimental confirmation available.; Name=4; IsoId=Q15185-4; Sequence=VSP_055365; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=14 uM for PGH2 ; Vmax=190 nmol/min/mg enzyme toward PGH2 ;
Catalytic Activity(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15- hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15- dihydroxy-9-oxoprosta-5,13-dienoate.
DomainThe PXLE motif mediates interaction with EGLN1/PHD2.
FunctionCytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448). {ECO
InteractionQ9UKV8:AGO2; NbExp=3; IntAct=EBI-1049387, EBI-528269; P07900:HSP90AA1; NbExp=6; IntAct=EBI-1049387, EBI-296047; O14654:IRS4; NbExp=2; IntAct=EBI-1049387, EBI-356594;
PathwayLipid metabolism; prostaglandin biosynthesis.
SimilarityBelongs to the p23/wos2 family.
SimilarityContains 1 CS domain. {ECO
Subcellular LocationCytoplasm.
SubunitBinds to the progesterone receptor. Interacts with TERT; the interaction, together with HSP90AA1, is required for correct assembly and stabilization of the telomerase holoenzyme complex. Interacts (via PXLE motif) with EGLN1/PHD2, recruiting EGLN1/PHD2 to the HSP90 pathway to facilitate HIF alpha proteins hydroxylation. {ECO