LMPD Database

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LMP000665

UniProt Annotations

Entry Information
Gene Nameinositol 1,4,5-triphosphate receptor 3
Protein EntryITPR3_MOUSE
UniProt IDP70227
SpeciesMouse
Comments
Comment typeDescription
DomainThe receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand- binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
FunctionReceptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. {ECO:0000269|PubMed:20813840, ECO:0000269|PubMed:21030605}.
PtmPhosphorylated on tyrosine residues (By similarity). Phosphorylated by AKT1 on serine and/or threonine residues. {ECO:0000250, ECO:0000269|PubMed:17242355, ECO:0000269|PubMed:21030605}.
SimilarityBelongs to the InsP3 receptor family. {ECO:0000305}.
SimilarityContains 5 MIR domains. {ECO:0000255|PROSITE- ProRule:PRU00131}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:15632133, ECO:0000269|PubMed:21030605}; Multi- pass membrane protein {ECO:0000269|PubMed:15632133, ECO:0000269|PubMed:21030605}.
SubunitHomotetramer. Interacts with TRPC1, TRPC3, TRPC4 and CABP1 (By similarity). Interacts with SIGMAR1, AKT1 and PML. Interacts with TMBIM4/LFG4. Interacts with CEMIP (By similarity). Interacts with LRMP (via coiled-coil domain). Interacts with TESPA1. {ECO:0000250, ECO:0000269|PubMed:11149946, ECO:0000269|PubMed:20071408, ECO:0000269|PubMed:21030605, ECO:0000269|PubMed:23650607}.