LMPD Database

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LMP000660

UniProt Annotations

Entry Information
Gene Nameapolipoprotein B receptor
Protein EntryAPOBR_MOUSE
UniProt IDQ8VBT6
SpeciesMouse
Comments
Comment typeDescription
Developmental StageFinds at the highest levels in E7, then progressively lower at E11 and E15, and finally very diminished at the E17. {ECO:0000269|PubMed:12177162}.
FunctionMacrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG- VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macrophages. {ECO:0000269|PubMed:12177162}.
InductionIncreased in high-fat diet ATM (adipose tissue macrophages). {ECO:0000269|PubMed:17192460}.
PtmThere are 2 forms in macrophages, the membrane-binding proteins 200 kDa (MBP 200) and 235 kDa (MBP 235), that can be reduced into a single active ligand-binding species with intermediate mobility (MBP 200R). {ECO:0000250}.
Subcellular LocationCell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Binds monocyte-macrophage membrane. Thought to be anchored in the membrane through an interaction with an integral membrane protein (By similarity). {ECO:0000250}.
SubunitHomodimer. {ECO:0000250}.
Tissue SpecificityHighly expressed in spleen, lung and skeletal muscle, and weakly in brain, heart, kidney, and testis. {ECO:0000269|PubMed:12177162}.