LMPD Database

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LMP000655

UniProt Annotations

Entry Information
Gene Namealdehyde dehydrogenase 1 family, member A2
Protein EntryAL1A2_HUMAN
UniProt IDO94788
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=O94788-1; Sequence=Displayed; Name=2; IsoId=O94788-2; Sequence=VSP_017363; Note=No experimental confirmation available.; Name=3; IsoId=O94788-3; Sequence=VSP_044496; Note=No experimental confirmation available.; Name=4; IsoId=O94788-4; Sequence=VSP_047259;
Catalytic ActivityRetinal + NAD(+) + H(2)O = retinoate + NADH.
FunctionRecognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently (By similarity).
PathwayCofactor metabolism; retinol metabolism.
SimilarityBelongs to the aldehyde dehydrogenase family.
Subcellular LocationCytoplasm.
SubunitHomotetramer.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/aldh1a2/";