LMPD Database

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LMP000626

UniProt Annotations

Entry Information
Gene Nameannexin A2
Protein EntryANXA2_MOUSE
UniProt IDP07356
SpeciesMouse
Comments
Comment typeDescription
DomainA pair of annexin repeats may form one binding site for calcium and phospholipid.
FunctionCalcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity.
InteractionP08207:S100a10; NbExp=2; IntAct=EBI-738510, EBI-643986;
MiscellaneousIt may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.
PtmISGylated. {ECO:0000269|PubMed:16139798}.
SimilarityBelongs to the annexin family. {ECO:0000305}.
SimilarityContains 4 annexin repeats. {ECO:0000305}.
Subcellular LocationSecreted, extracellular space, extracellular matrix, basement membrane. Melanosome {ECO:0000250}. Note=In the lamina beneath the plasma membrane.
SubunitHeterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with DYSF. Interacts with ATP1B1 (By similarity). Interacts with COCH (By similarity). {ECO:0000250}.
Web ResourceName=Protein Spotlight; Note=Red velvet - Issue 86 of September 2007; URL="http://web.expasy.org/spotlight/back_issues/086";