LMPD Database

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LMP000612

UniProt Annotations

Entry Information
Gene Nameserum deprivation response
Protein EntryO95810_HUMAN
UniProt IDO95810
SpeciesHuman
Comments
Comment typeDescription
FunctionMay play a role in targeting PRKCA to caveolae.
InductionUp-regulated in asyncronously growing fibroblasts following serum deprivation but not following contact inhibition. Down-regulated during synchronous cell cycle re-entry.
InteractionP08567:PLEK; NbExp=4; IntAct=EBI-742141, EBI-2565501;
MiscellaneousBinds phosphatidylserine (PS) in a calcium- independent manner. PS-binding is inhibited by phosphotidic acid and phosphatidylinositol. Does not bind phosphatidylcholine.
PtmPhosphorylated on Ser residues. {ECO
SimilarityBelongs to the PTRF/SDPR family.
Subcellular LocationCytoplasm, cytosol. Membrane, caveola. Note=Colocalizes with CAV1 to caveolae.
SubunitBinds to PRKCA in the presence of phosphatidylserine (By similarity). Interacts with MURC; this augments the transactivation of NPPA by MURC. {ECO
Tissue SpecificityHighly expressed in heart and lung, and expressed at lower levels in brain, kidney, liver, pancreas, placenta, and skeletal muscle.