LMPD Database

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LMP000610

UniProt Annotations

Entry Information
Gene Namecarbonyl reductase 2
Protein EntryCBR2_MOUSE
UniProt IDP08074
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityR-CHOH-R' + NADP(+) = R-CO-R' + NADPH.
FunctionMay function in the pulmonary metabolism of endogenous carbonyl compounds, such as aliphatic aldehydes and ketones derived from lipid peroxidation, 3-ketosteroids and fatty aldehydes, as well as in xenobiotic metabolism. {ECO:0000269|PubMed:7705352}.
InductionBy glucocorticoids. Activated by fatty acids.
MiscellaneousUses both NADP and NAD as substrates. Has a strong preference for NADP.
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular LocationMitochondrion matrix {ECO:0000269|PubMed:8040004}.
SubunitHomotetramer. {ECO:0000269|PubMed:8805511}.
Tissue SpecificityLung (ciliated cells, non-ciliated bronchiolar cells and type-II alveolar pneumocytes). Low expression in adipose tissue > testis = heart > kidney = spleen > brain = liver.