LMPD Database

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LMP000607

UniProt Annotations

Entry Information
Gene Namemicrosomal triglyceride transfer protein
Protein EntryMTP_MOUSE
UniProt IDO08601
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative promoter usage; Named isoforms=2; Name=1; Synonyms=MTP-A; IsoId=O08601-1; Sequence=Displayed; Name=2; Synonyms=MTPv1, MTP-B; IsoId=O08601-2; Sequence=VSP_038546; Note=Cleaved by signal peptidase between residues Gln-33 and Asn-34 (PubMed:17312007 and PubMed:17635917).;
Developmental StageExpression in the yolk sac tissues followed by expression in the primordial liver cell nests as early as day 9 post-coitum (E9.5). Intestinal expression is detected around E12.5 and attains full adult expression patterns by E14.5. {ECO:0000269|PubMed:10744773}.
Disruption PhenotypeLowers plasma and tissue triglyceride levels, and increases cellular free cholesterol. {ECO:0000269|PubMed:10713055, ECO:0000269|PubMed:18502767}.
FunctionCatalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B. May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins. Loads phospholipid into the C1D1 antigen-binding groove. Isoform 2 is critical for the development of natural killer T (NKT) cells. May have a role in the biogenesis of lipid droplets. {ECO:0000269|PubMed:17312007, ECO:0000269|PubMed:17635917, ECO:0000269|PubMed:18502767}.
InductionUp-regulated by FOXO1. {ECO:0000269|PubMed:18497885}.
SimilarityContains 1 vitellogenin domain. {ECO:0000255|PROSITE- ProRule:PRU00557}.
Subcellular LocationIsoform 1: Endoplasmic reticulum. Note=Localized to the endoplasmic reticulum according to PubMed:17312007.
Subcellular LocationIsoform 2: Endoplasmic reticulum. Golgi apparatus. Note=Localized to the endoplasmic reticulum according to PubMed:17312007. Localized to the Golgi apparatus according to PubMed:17635917.
SubunitHeterodimer composed of MTTP and of protein disulfide isomerase (P4HB/PDI).
Tissue SpecificityExpressed in heart. Isoform 1 is mainly expressed in the intestine and the liver, and at lower levels in white and brown fat cells. Isoform 2 is ubiquitous, and is the major isoform in hematopoietic cells and adipocytes. {ECO:0000269|PubMed:17312007, ECO:0000269|PubMed:17635917, ECO:0000269|PubMed:9502759}.