Comment type | Description |
Alternative Products | Event=Alternative splicing; Named isoforms=5; Name=B; IsoId=P06401-1; Sequence=Displayed; Name=A; IsoId=P06401-2; Sequence=VSP_003706; Name=3; IsoId=P06401-3; Sequence=VSP_046942; Name=4; Synonyms=PR-M; IsoId=P06401-4; Sequence=VSP_047454, VSP_047455; Name=5; Synonyms=delta4; IsoId=P06401-5; Sequence=VSP_053543; |
Domain | Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. |
Function | Isoform 4: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone. |
Function | Isoform A |
Function | The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation. |
Interaction | Q9H467:CUEDC2; NbExp=9; IntAct=EBI-78539, EBI-1248228; P40763:STAT3; NbExp=3; IntAct=EBI-78539, EBI-518675; |
Ptm | Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation. |
Ptm | Phosphorylated on multiple serine sites. Several of these sites are hormone-dependent. Phosphorylation on Ser-294 occurs preferentially on isoform B, is highly hormone-dependent and modulates ubiquitination and sumoylation on Lys-388. Phosphorylation on Ser-102 and Ser-345 also requires induction by hormone. Basal phosphorylation on Ser-81, Ser-162, Ser-190 and Ser-400 is increased in response to progesterone and can be phosphorylated in vitro by the CDK2-A1 complex. Increased levels of phosphorylation on Ser-400 also in the presence of EGF, heregulin, IGF, PMA and FBS. Phosphorylation at this site by CDK2 is ligand-independent, and increases nuclear translocation and transcriptional activity. Phosphorylation at Ser-162 and Ser-294, but not at Ser-190, is impaired during the G(2)/M phase of the cell cycle. Phosphorylation on Ser-345 by ERK1/2 MAPK is required for interaction with SP1. {ECO |
Ptm | Sumoylation is hormone-dependent and represses transcriptional activity. Sumoylation on all three sites is enhanced by PIAS3. Desumoylated by SENP1. Sumoylation on Lys-388, the main site of sumoylation, is repressed by ubiquitination on the same site, and modulated by phosphorylation at Ser-294. {ECO |
Ptm | Ubiquitination is hormone-dependent and represses sumoylation on the same site. Promoted by MAPK-mediated phosphorylation on Ser-294. {ECO |
Similarity | Belongs to the nuclear hormone receptor family. NR3 subfamily. |
Similarity | Contains 1 nuclear receptor DNA-binding domain. |
Subcellular Location | Isoform 4: Mitochondrion outer membrane . |
Subcellular Location | Isoform A |
Subcellular Location | Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases. |
Subunit | Interacts with SMARD1 and UNC45A. Interacts with CUEDC2; the interaction promotes ubiquitination, decreases sumoylation, and repesses transcriptional activity. Interacts with PIAS3; the interaction promotes sumoylation of PR in a hormone-dependent manner, inhibits DNA-binding, and alters nuclear export. Interacts with SP1; the interaction requires ligand-induced phosphorylation on Ser-345 by ERK1/2 MAPK. Interacts with PRMT2. {ECO |
Web Resource | Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/pgr/"; |
Web Resource | Name=Wikipedia; Note=Progesterone receptor entry; URL="http://en.wikipedia.org/wiki/Progesterone_receptor"; |