LMPD Database

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LMP000587

UniProt Annotations

Entry Information
Gene NameUDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
Protein EntryB3GN1_HUMAN
UniProt IDO43505
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityUDP-N-acetyl-D-glucosamine + beta-D- galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta- D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-D- glucosaminyl-R.
DiseaseMuscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A13 (MDDGA13) [MIM
FunctionCan initiate the synthesis or the elongation of the linear poly-N-acetyllactosaminoglycans. Involved in alpha- dystroglycan (DAG1) glycosylation. {ECO
PathwayProtein modification; protein glycosylation.
SimilarityBelongs to the glycosyltransferase 49 family.
Subcellular LocationGolgi apparatus membrane ; Single-pass type II membrane protein .
Tissue SpecificityIn the adult, highly expressed in heart, brain, skeletal muscle and kidney and to a lesser extent in placenta, pancreas, spleen, prostate, testis, ovary, small intestine and colon. Very weak expression in lung, liver, thymus and peripheral blood leukocytes. In fetal highly expressed in brain and kidney and to a lesser extent in lung and liver.
Web ResourceName=Functional Glycomics Gateway - GTase; Note=N- acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_547";
Web ResourceName=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=B3GNT1";
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/b3gnt6/";