LMPD Database

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LMP000560

UniProt Annotations

Entry Information
Gene Namesignal transducer and activator of transcription 5B
Protein EntrySTA5B_MOUSE
UniProt IDP42232
SpeciesMouse
Comments
Comment typeDescription
Developmental StageDetected both in virgin mouse and after mammary gland involution. The level of STAT5A increases constantly during pregnancy, but decreases during lactation.
FunctionCarries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. {ECO:0000269|PubMed:11773439}.
InteractionQ96EY1:DNAJA3 (xeno); NbExp=3; IntAct=EBI-617454, EBI-356767; Q96EY1-1:DNAJA3 (xeno); NbExp=2; IntAct=EBI-617454, EBI-4322330; Q96EY1-2:DNAJA3 (xeno); NbExp=2; IntAct=EBI-617454, EBI-3952284; P19941:GHR (xeno); NbExp=6; IntAct=EBI-617454, EBI-7526279;
PolymorphismThe polymorphism at position 327 in strain NOD reduces DNA-binding affinity.
PtmTyrosine phosphorylated. Tyrosine phosphorylated in response to signaling via activated KIT, resulting in translocation to the nucleus. Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2 (By similarity). Phosphoryation at Tyr-699 by PTK6 or HCK leads to an increase of its transcriptional activity (By similarity). Dephosphorylation on tyrosine residues by PTPN2 negatively regulates prolactin signaling pathway. {ECO:0000250, ECO:0000269|PubMed:11090077, ECO:0000269|PubMed:11773439, ECO:0000269|PubMed:21135090, ECO:0000269|PubMed:21262971}.
SimilarityBelongs to the transcription factor STAT family. {ECO:0000305}.
SimilarityContains 1 SH2 domain. {ECO:0000255|PROSITE- ProRule:PRU00191}.
Subcellular LocationCytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
SubunitForms a homodimer or a heterodimer with a related family member. Interacts with SOCS7 (By similarity). Binds NR3C1 and NCOA1. Interacts (via SH2 domain) with INSR. {ECO:0000250, ECO:0000269|PubMed:9428692, ECO:0000269|PubMed:9528750}.
Tissue SpecificityIn the virgin, found in most tissues. Particularly abundant in muscle tissue of virgin and lactating females, and of males.