LMPD Database

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LMP000549

UniProt Annotations

Entry Information
Gene Namecaveolin 1, caveolae protein
Protein EntryCAV1_MOUSE
UniProt IDP49817
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative initiation; Named isoforms=2; Name=1; IsoId=P49817-1; Sequence=Displayed; Name=2; IsoId=P49817-2; Sequence=VSP_018693;
FunctionInvolved in the costimulatory signal essential for T- cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G- protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. {ECO:0000269|PubMed:10816572}.
InteractionQ07820:MCL1 (xeno); NbExp=3; IntAct=EBI-1161338, EBI-1003422; P22307:SCP2 (xeno); NbExp=3; IntAct=EBI-1161338, EBI-1050999;
PtmPhosphorylated at Tyr-14 by ABL1 in response to oxidative stress. {ECO:0000269|PubMed:12036959, ECO:0000269|PubMed:12531427}.
PtmThe N-terminus of both isoforms are blocked.
SimilarityBelongs to the caveolin family. {ECO:0000305}.
Subcellular LocationGolgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Membrane, caveola {ECO:0000269|PubMed:21610094}; Peripheral membrane protein {ECO:0000269|PubMed:21610094}. Membrane raft {ECO:0000250}. Note=Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity). {ECO:0000250}.
SubunitHomooligomer (By similarity). Interacts (via the N- terminus) with DPP4; the interaction is direct (By similarity). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Interacts with BMX, BTK, CTNNB1, CDH1, GLIPR2, JUP, NOSTRIN, SNAP25 and STX1A. Interacts with SLC7A9 (By similarity). Interacts with PACSIN2. {ECO:0000250, ECO:0000269|PubMed:21610094}.