LMPD Database

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LMP000529

UniProt Annotations

Entry Information
Gene NameAU RNA binding protein/enoyl-coenzyme A hydratase
Protein EntryAUHM_MOUSE
UniProt IDQ9JLZ3
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9JLZ3-1; Sequence=Displayed; Name=2; IsoId=Q9JLZ3-2; Sequence=VSP_008337, VSP_008340; Note=No experimental confirmation available.; Name=3; IsoId=Q9JLZ3-3; Sequence=VSP_008338, VSP_008339; Note=No experimental confirmation available.;
Catalytic Activity(S)-3-hydroxy-3-methylglutaryl-CoA = trans-3- methylglutaconyl-CoA + H(2)O.
FunctionCatalyzes the conversion of 3-methylglutaconyl-CoA to 3- hydroxy-3-methylglutaryl-CoA. Has very low enoyl-CoA hydratase activity. Was originally identified as RNA-binding protein that binds in vitro to clustered 5'-AUUUA-3' motifs (By similarity). {ECO:0000250}.
PathwayAmino-acid degradation; L-leucine degradation; (S)-3- hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 3/3.
SimilarityBelongs to the enoyl-CoA hydratase/isomerase family. {ECO:0000305}.
Subcellular LocationMitochondrion {ECO:0000269|PubMed:10072761}.
SubunitHomohexamer. {ECO:0000250}.
Tissue SpecificityDetected in heart, brain, liver, spleen, skeletal muscle and kidney. {ECO:0000269|PubMed:10072761}.