LMPD Database

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LMP000496

UniProt Annotations

Entry Information
Gene Namesterol-C5-desaturase
Protein EntrySC5D_HUMAN
UniProt IDO75845
SpeciesHuman
Comments
Comment typeDescription
Catalytic Activity5-alpha-cholest-7-en-3-beta-ol + NAD(P)H + O(2) = cholesta-5,7-dien-3-beta-ol + NAD(P)(+) + 2 H(2)O.
CofactorName=Fe cation; Xref=ChEBI
DiseaseLathosterolosis (LATHST) [MIM
DomainThe histidine box domains may contain the active site and/or be involved in metal ion binding.
FunctionCatalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol.
SimilarityBelongs to the sterol desaturase family.
Subcellular LocationEndoplasmic reticulum membrane {ECO