LMPD Database

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LMP000486

UniProt Annotations

Entry Information
Gene Nameglycoprotein galactosyltransferase alpha 1, 3
Protein EntryQ9DBU1_MOUSE
UniProt IDQ9DBU1
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=P23336-1; Sequence=Displayed; Name=2; IsoId=P23336-2; Sequence=VSP_001804; Name=3; IsoId=P23336-3; Sequence=VSP_001804, VSP_001805;
Catalytic ActivityUDP-alpha-D-galactose + beta-D-galactosyl- (1->4)-beta-N-acetyl-D-glucosaminyl-R = UDP + alpha-D-galactosyl- (1->3)-beta-D-galactosyl-(1->4)-beta-N-acetylglucosaminyl-R.
CofactorName=Mn(2+); Xref=ChEBI:CHEBI:29035;
DomainThe conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis.
FunctionSynthesizes the galactose-alpha(1,3)-galactose group by catalyzing the transfer of a galactose residue, with an alpha-1,3 linkage, on terminal lactosaminide (Gal-beta-1,4-GlcNAc-R) disaccharide borne by a glycoprotein or a glycolipid. Preferentially glycosylates proteins, can synthesize galactose- alpha(1,3)-galactose on glycoproteins but cannot synthesize the glycolipid called isoglobotrihexosylceramide or isogloboside 3 (iGb3). {ECO:0000269|PubMed:12626403}.
PathwayProtein modification; protein glycosylation.
SimilarityBelongs to the glycosyltransferase 6 family. {ECO:0000305}.
Subcellular LocationGolgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.