LMPD Database

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LMP000458

UniProt Annotations

Entry Information
Gene Name3-oxoacyl-ACP synthase, mitochondrial
Protein EntryOXSM_HUMAN
UniProt IDQ9NWU1
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NWU1-1; Sequence=Displayed; Name=2; IsoId=Q9NWU1-2; Sequence=VSP_041671;
Biophysicochemical PropertiesKinetic parameters: KM=3.9 uM for C4-[acyl-carrier-protein] ; KM=1.9 uM for C6-[acyl-carrier-protein] ; KM=10.9 uM for C8-[acyl-carrier-protein] ; KM=1.8 uM for C10-[acyl-carrier-protein] ; KM=9.5 uM for C12-[acyl-carrier-protein] ; KM=50.8 uM for C14-[acyl-carrier-protein] ; Vmax=129 nmol/min/mg enzyme toward C4-[acyl-carrier-protein] ; Vmax=241 nmol/min/mg enzyme toward C6-[acyl-carrier-protein] ; Vmax=271 nmol/min/mg enzyme toward C8-[acyl-carrier-protein] ; Vmax=364 nmol/min/mg enzyme toward C10-[acyl-carrier-protein] ; Vmax=1045 nmol/min/mg enzyme toward C12-[acyl-carrier-protein] ; Vmax=115 nmol/min/mg enzyme toward C14-[acyl-carrier-protein] ; Note=The highest catalytic efficiency is observed for C10-[acyl- carrier-protein].;
Catalytic ActivityAcyl-[acyl-carrier-protein] + malonyl-[acyl- carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO(2) + [acyl-carrier-protein].
Enzyme RegulationInhibited by cerulenin.
FunctionMay play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.
PathwayLipid metabolism; fatty acid biosynthesis.
SimilarityBelongs to the beta-ketoacyl-ACP synthases family.
Subcellular LocationMitochondrion .
Tissue SpecificityWidely expressed. Higher expression in heart, skeletal muscle, liver and kidney which contain high levels of active mitochondria.