LMPD Database

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LMP000449

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 2, subfamily B, polypeptide 6
Protein EntryCP2B6_HUMAN
UniProt IDP20813
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P20813-1; Sequence=Displayed; Name=2; IsoId=P20813-2; Sequence=VSP_055571, VSP_055572; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=360 uM for 1,4-cineole ; Vmax=3.4 nmol/min/nmol enzyme toward 2-exo-hydroxy-1,4-cineole ;
Catalytic Activity1,4-cineole + NADPH + O(2) = 2-exo-hydroxy- 1,4-cineole + NADP(+) + H(2)O.
CofactorName=heme; Xref=ChEBI
FunctionCytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase. {ECO
InductionBy phenobarbital.
PolymorphismGenetic variations in CYP2B6 are responsible for poor metabolism of efavirenz and, therefore, susceptibility to efavirenz toxicity in the central nervous system [MIM
PtmPhosphorylation is accompanied by a decrease in enzyme activity.
SimilarityBelongs to the cytochrome P450 family.
Subcellular LocationEndoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue SpecificityExpressed in liver, lung and heart right ventricle.
Web ResourceName=Cytochrome P450 Allele Nomenclature Committee; Note=CYP2B6 alleles; URL="http://www.cypalleles.ki.se/cyp2b6.htm";
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cyp2b6/";