LMPD Database

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LMP000432

UniProt Annotations

Entry Information
Gene NameFc receptor, IgE, high affinity I, alpha polypeptide
Protein EntryFCERA_MOUSE
UniProt IDP20489
SpeciesMouse
Comments
Comment typeDescription
FunctionBinds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.
InductionExhibits night/day variations with an increased expression at night in the pineal gland. {ECO:0000269|PubMed:17728245}.
SimilarityContains 2 Ig-like (immunoglobulin-like) domains. {ECO:0000305}.
Subcellular LocationCell membrane; Single-pass type I membrane protein.
SubunitTetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains.
Tissue SpecificityExpressed in bone marrow mast cells, as well as in the pineal gland at night. {ECO:0000269|PubMed:17728245}.